Independent Work

coming soon...

Supervised Work

14. You-Chen Lin, Fabian Schneider, Kelly J. Eberle, Debora Chiodi, Hugh Nakamura, Solomon H. Reisberg, Jason Chen, Masato Saito, Phil S. Baran

      "Atroposelective Total Synthesis of Darobactin A” 

       J. Am. Chem. Soc. 2022, Just Accepted

13. Hugh Nakamura, Kosuke Yasui, Phil S. Baran

      "Total Synthesis of Teleocidins B-1-B-4 by Redox-Relay Chain Walking (RRCW)” 

       J. Synth. Org. Chem. Jpn. 2021, 79, 333−343

12. Yuzuru Kanda, Hugh Nakamura, Shigenobu Umemiya, Ravi Kumar Puthukanoori, Venkata Ramana Murthy Appala,   

      Gopi Krishna Gaddamanugu, Bheema Rao Paraselli, Phil S. Baran

      "Two-Phase Synthesis of Taxol”

       J. Am. Chem. Soc. 2020, 142, 10526−10533

 

11. Hugh Nakamura, Chihiro Tsukano, Takuma Yoshida, Motohiro Yasui, Shinsuke Yokouchi, Yusuke Kobayashi, Masayuki   

      Igarashi, Yoshiji Takemoto

      “Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a 

       Fatty Acid Side Chain to 1,4-Diazepanone”

       J. Am. Chem. Soc. 2019, 141, 8527–8540

10. Hugh Nakamura, Kosuke Yasui, Yuzuru Kanda, Phil S. Baran

      “11-Step Total Synthesis of Teleocidins B-1–B-4”

       J. Am. Chem. Soc. 2019, 141, 1494–1497

09. Hugh Nakamura, Manami Kawakami, Chihiro Tsukano, Yoshiji Takemoto 

      "Construction of ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a

      Tetra-substituted Olefin”

      Synlett 2019, 30, 2253–2257 

 

08. Hugh Nakamura, Manami Kawakami, Chihiro Tsukano, Yoshiji Takemoto

      "Concise construction of the ACDE ring system of calyciphylline A type alkaloids by a [5+2] cycloaddition”

       Chem. Eur. J. 2019, 25, 8701–8704

 

07. Yu K.awamata, Julien C. Vantourout, David P. Hickey, Peng Bai, Longrui Chen, Qinglong Hou, Wenhua Qiao, Koushik

      Barman, Martin Edwards, Alberto G. Castro, David S. Peters, Justine N. deGruyter, Hugh Nakamura, Kyle Knouse,

      Chuanguang Qin, Khalyd J. Clay, Denghui Bao, Chao Li, Jeremy T. Starr, Neal Sach, Martin D. Eastgate, Matthew Neurock,

      Shelly D. Minteer, Henry White, Phil S. Baran

      “Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications”

       J. Am. Chem. Soc. 2019, 141, 63926402

 

 

06. Yusuke Takahira, Miao Chen, Yu Kawamata, Pavel Mykhailiuka, Hugh Nakamura, Byron K. Peters, Solomon H. Reisberg,

      Chao Li, Longrui Chen, Tamaki Hoshikawa, Tomoyuki Shibuguchi, Phil S. Baran

      "Electrochemical C(sp3)–H Fluorination”

      Synlett 2019, 30, 1178–1182

 

05. Chao Li, Yu Kawamata, Hugh Nakamura, Julien C. Vantourout, Zhiqing Liu, Qinglong Hou, Denghui Bao, Jeremy T. Starr,

       Jinshan Chen, Ming Yan, Phil S. Baran

      “Electrochemically Enabled, Nickel-Catalyzed Amination”

       Angew. Chem. Int. Ed. 2017, 56, 13088–13093  

 

04. Hugh Nakamura

      "Synthetic studies toward total synthesis of caprazamycins and calyciphylline A type alkaloids”

       Dissertation (Ph.D. thesis) 2017, Kyoto University 

 

 

03. Hugh Nakamura, Takuma Yoshida, Chihiro Tsukano, Yoshiji Takemoto

       "Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-catalyzed Intramolecular Amidation of a 

       Vinyl Iodide”

       Org. Lett. 2016, 18, 2300–2303

 

02. Hugh Nakamura, Chihiro Tsukano, Motohiro Yasui, Shinsuke Yokouchi, Masayuki Igarashi, Yoshiji Takemoto

      “Total Synthesis of (-)-Caprazamycin A”

       Angew. Chem. Int. Ed. 2015, 54, 3136–3139

 

01. Yuta Yanagita, Hugh Nakamura, Kenji Shirokane, Yusuke Kurosaki, Takaaki Sato, Noritaka Chida

       “Direct Nucleophilic Addition to N-Alkoxyamides”

       Chem. Eur. J. 2013, 19, 678–684 

Major Books and Other Publications

3. Hugh Nakamura

    "To win away games"

     Division of Organometallic Chemistry, Kinka Chemical Society, Japan (Organometallic News (OM News) No. 1), issued on March 18, 2022

2. Hugh Nakamura

    "How to survive in the big lab in US"

     Division of Medicinal Chemistry at The Pharmaceutical Society of Japan (MEDCHEM NEWS Vol.31 No1), 2021 

1. Hugh Nakamura, Chihiro Tsukano, Yoshiji Takemoto

    "Latest Trends in Total Synthesis of Natural Products "

     CMC Publishing CO. LTD.  Mar 15, 2020  

    (Area of responsibility: Total Synthesis of Caprazamycin A, a Liponucleoside having Fatty Acids Side Chain)

 Invited Talk

5. 54th Summer Seminar for Young Peptide Scientist, "Total synthesis of highly complex natural products"

     (Tokyo, Japan, Aug. 2022, Zoom webinar), URL: https://www.peptide-soc.jp/event/news/2022/07/01/54wakate.html

4. The 4th Organic Chemistry Student Webinar, "Total synthesis of highly potent bioactive natural products"

     (Tokyo, Japan, Jan. 2022, Zoom webinar), URL: https://connpass.com/event/230899/

3. Research presentation, Department of Chemistry, The Hong Kong University of Science and Technology, "Total synthesis of highly potent       

     bioactive natural products"

    (Hong Kong, Feb. 2021, Zoom webinar)

2. Meeting of Minds@HKU Forum for Outstanding Young Scholars, "The Art and Science of Drug Discovery"

    (Hong Kong, October 2019)

1. Research presentation, Georg-August-University Göttingen, "Total Synthesis of Amino acid Containing Natural Products"

    (Göttingen, Germany, July 2019)