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Nakamura Lab @HKUST

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Independent Work

27. L. Yu, § J. Zhang, § X. Zhang, § X. Wu, § R. Liu, C. H. Au, H. Ogawa, R. Tong,* H. Nakamura*

      "Unified Access to Biaryl-Bridged Linkages Unlocks Structural Diversification of Noncanonical Cyclic Peptides” 

       (§These authors contributed equally.)

       ChemRxiv 2026

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26. H. Ogawa §, L. Yu §, S. Li, Y. Nagata, T.-K. Chan, Y. Matsuda, J. Liu, Y.-X. Li, H. Nakamura*

      "Reprogramming RiPP Scaffolds through Skeletal Editing Unlocks Chemical Space” 

       (§These authors contributed equally.)

       ChemRxiv 2026

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25. J. Zhang, H. Nakamura*

      "Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease” 

       Angew. Chem. Int. Ed. 2026, e26149

 

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24. H. Ogawa, H. Nakamura*

      "Advances in Zr-Mediated Radical Transformations and Applications to Total Synthesis” 

       Beilstein J. Org. Chem. 2026, 22, 71–87 (Invited contribution)

       Special issue “Concept-driven strategies in target-oriented synthesis” in the Beilstein Journal of Organic Chemistry.

 

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23. H. Ogawa, Y. Nagata, T.-K. Chan, Y. Matsuda, H. Nakamura*

      "Rapid Construction of a Tyr C6–Trp C5′ Linkage: Application in the Total Synthesis of Micitide 982, a Noncanonical Cyclic Peptide” 

       Angew. Chem. Int. Ed. 2025, 64, e202516053

 

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22. L. Yu §, S. Li §, H. Ogawa §, Y. Ma, Q. Chen, K. Yamazaki, Y. Nagata*, H. Nakamura*

      "Fe-Electrocatalytic Deoxygenative Giese Reaction” 

       (§These authors contributed equally.)

       Nat. Commun. 2025​, 16, 8379

   

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21. L. Yu §, H. Ogawa §, S. Li §, T.-L. Cheung §, W. Liu, D. Yan, Y. Matsuda, Y. Kobayashi, Z. Guo, K. Ikeda, T. A. Hamlin,

      K. Yamazaki*, P.-Y. Qian*, H. Nakamura*

      "Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr-catalyzed Dimerization” 

       (§These authors contributed equally.)

       Angew. Chem. Int. Ed. 2025, 64, e202414295

       (Highlighted in Synfacts)

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20. J. Zhang §, L. Yu §, H. Ogawa, Y. Nagata, H. Nakamura*

      "Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage” 

       (§These authors contributed equally.)​​​​

       Angew. Chem. Int. Ed. 2024, 63, e202409987

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19. H. Nakamura*

       "Introducing …" 

      Angew. Chem. Int. Ed. 2024, 63, e202415362​​​

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18. L. Yu, Y. Nagata, H. Nakamura*

      "Atroposelective Total Synthesis of Cihunamide B” 

       J. Am. Chem. Soc. 2024, 146, 2549–2555

      (Highlighted in Chem-Station)

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17. H. Ogawa, H. Nakamura*

      "Atroposelective Total Synthesis of Strecintide 839” 

       Tetrahedron Chem, 2024, 11, 100084 (Invited contribution)

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16. H. Ogawa, Y. Nagata, H. Nakamura*

      "Modular, Scalable Total Synthesis of Neopetromin” 

       Chin. J. Chem., 2024, 42, 3023−3028 (Invited contribution)

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15. L. Yu, H. Nakamura*

      "Short, Scalable Access to Pyrrovobasine” 

       JACS Au 2023, 3, 3000−3004

      (Highlighted in Chem-Station)

      (Highlighted in Waser's group meeting)

      (Selected as the Most Read Article of the Month)

      (Selected as the Most Read Article of the Year)

       

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Supervised Work

14. You-Chen Lin, Fabian Schneider, Kelly J. Eberle, Debora Chiodi, Hugh Nakamura, Solomon H. Reisberg, Jason Chen, Masato Saito, Phil S. Baran

      "Atroposelective Total Synthesis of Darobactin A” 

       J. Am. Chem. Soc. 2022, 144, 14458–14462

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13. Hugh Nakamura, Kosuke Yasui, Phil S. Baran

      "Total Synthesis of Teleocidins B-1-B-4 by Redox-Relay Chain Walking (RRCW)” 

       J. Synth. Org. Chem. Jpn. 2021, 79, 333−343

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12. Yuzuru Kanda, Hugh Nakamura, Shigenobu Umemiya, Ravi Kumar Puthukanoori, Venkata Ramana Murthy Appala,   

      Gopi Krishna Gaddamanugu, Bheema Rao Paraselli, Phil S. Baran

      "Two-Phase Synthesis of Taxol”

       J. Am. Chem. Soc. 2020, 142, 10526−10533

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11. Hugh Nakamura, Chihiro Tsukano, Takuma Yoshida, Motohiro Yasui, Shinsuke Yokouchi, Yusuke Kobayashi, Masayuki   

      Igarashi, Yoshiji Takemoto

      “Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a 

       Fatty Acid Side Chain to 1,4-Diazepanone”

       J. Am. Chem. Soc. 2019, 141, 8527–8540

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10. Hugh Nakamura, Kosuke Yasui, Yuzuru Kanda, Phil S. Baran

      “11-Step Total Synthesis of Teleocidins B-1–B-4”

       J. Am. Chem. Soc. 2019, 141, 1494–1497

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09. Hugh Nakamura, Manami Kawakami, Chihiro Tsukano, Yoshiji Takemoto 

      "Construction of ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a

      Tetra-substituted Olefin”

      Synlett 2019, 30, 2253–2257 

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08. Hugh Nakamura, Manami Kawakami, Chihiro Tsukano, Yoshiji Takemoto

      "Concise construction of the ACDE ring system of calyciphylline A type alkaloids by a [5+2] cycloaddition”

       Chem. Eur. J. 2019, 25, 8701–8704

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07. Yu K.awamata, Julien C. Vantourout, David P. Hickey, Peng Bai, Longrui Chen, Qinglong Hou, Wenhua Qiao, Koushik

      Barman, Martin Edwards, Alberto G. Castro, David S. Peters, Justine N. deGruyter, Hugh Nakamura, Kyle Knouse,

      Chuanguang Qin, Khalyd J. Clay, Denghui Bao, Chao Li, Jeremy T. Starr, Neal Sach, Martin D. Eastgate, Matthew Neurock,

      Shelly D. Minteer, Henry White, Phil S. Baran

      “Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications”

       J. Am. Chem. Soc. 2019, 141, 6392–6402

 

 

06. Yusuke Takahira, Miao Chen, Yu Kawamata, Pavel Mykhailiuka, Hugh Nakamura, Byron K. Peters, Solomon H. Reisberg,

      Chao Li, Longrui Chen, Tamaki Hoshikawa, Tomoyuki Shibuguchi, Phil S. Baran

      "Electrochemical C(sp3)–H Fluorination”

      Synlett 2019, 30, 1178–1182

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05. Chao Li, Yu Kawamata, Hugh Nakamura, Julien C. Vantourout, Zhiqing Liu, Qinglong Hou, Denghui Bao, Jeremy T. Starr,

       Jinshan Chen, Ming Yan, Phil S. Baran

      “Electrochemically Enabled, Nickel-Catalyzed Amination”

       Angew. Chem. Int. Ed. 2017, 56, 13088–13093  

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04. Hugh Nakamura

      "Synthetic studies toward total synthesis of caprazamycins and calyciphylline A type alkaloids”

       Dissertation (Ph.D. thesis) 2017, Kyoto University 

 

 

03. Hugh Nakamura, Takuma Yoshida, Chihiro Tsukano, Yoshiji Takemoto

       "Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-catalyzed Intramolecular Amidation of a Vinyl Iodide”

       Org. Lett. 2016, 18, 2300–2303

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02. Hugh Nakamura, Chihiro Tsukano, Motohiro Yasui, Shinsuke Yokouchi, Masayuki Igarashi, Yoshiji Takemoto

      “Total Synthesis of (-)-Caprazamycin A”

       Angew. Chem. Int. Ed. 2015, 54, 3136–3139

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01. Yuta Yanagita, Hugh Nakamura, Kenji Shirokane, Yusuke Kurosaki, Takaaki Sato, Noritaka Chida

       “Direct Nucleophilic Addition to N-Alkoxyamides”

       Chem. Eur. J. 2013, 19, 678–684 

Major Books and Other Publications

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​​​3. Hugh Nakamura

    "To win away games"

     Division of Organometallic Chemistry, Kinka Chemical Society, Japan (Organometallic News (OM News) No. 1), issued on March 18, 2022

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2. Hugh Nakamura

    "How to survive in the big lab in US"

     Division of Medicinal Chemistry at The Pharmaceutical Society of Japan (MEDCHEM NEWS Vol.31 No1), 2021 

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1. Hugh Nakamura, Chihiro Tsukano, Yoshiji Takemoto

    "Latest Trends in Total Synthesis of Natural Products "

     CMC Publishing CO. LTD.  Mar 15, 2020  

    (Area of responsibility: Total Synthesis of Caprazamycin A, a Liponucleoside having Fatty Acids Side Chain)

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